Lipid Metabolism at Membrane Contacts: Dynamics and Functions Beyond Lipid Homeostasis

Golgi Membrane Dynamics and Lipid Metabolism

The striking morphology of the Golgi complex has fascinated cell biologists since its discovery over 100 years ago. Yet, despite intense efforts to understand how membrane flow relates to Golgi form and function, this organelle continues to baffle cell biologists and biochemists alike. Fundamental questions regarding Golgi function, while hotly debated, remain unresolved. Historically, Golgi fu...

Lipid rafts and membrane dynamics.

Cell membranes contain a variety of lipid species that differ in their physico-chemical properties. Lipid-lipid immiscibility gives rise to lateral heterogeneities in the membrane plane, a subset of which are termed lipid rafts (Simons and Vaz, 2004). Originally defined biochemically as detergentresistant membrane (DRM) fractions, lipid rafts are proposed to be highly dynamic, submicroscopic as...

Regulation of Lipid Metabolism and Beyond

One of the worldwide health issues is the increasing number of obese population. In 1975 it was less than 100 million but it reached 600 million in 2014 according to WHO report in 2015. More than one-third of adults and 17% of youth are obese in America [1, 2]. Obesity is one of the major risk factors for diverse human diseases and more and more research papers are coming to dissect the mechani...

Membrane and lipid dynamics at fertilization in sea urchin eggs

Lipid fluidity and membrane protein dynamics.

Membrane fluidity plays an important role in cellular functions. Membrane proteins are mobile in the lipid fluid environment; lateral diffusion of membrane proteins is slower than expected by theory, due to both the effect of protein crowding in the membrane and to constraints from the aqueous matrix. A major aspect of diffusion is in macromolecular associations: reduction of dimensionality for...